chorionic villous mesenchyme

A mesenchyme that is part of a chorionic villus.

Tipo Organ
Estrutura pai embryonic structure

Perguntas frequentes

What is chorionic villous mesenchyme?
Chorionic villous mesenchyme is the connective tissue core of a chorionic villus, comprising the stromal component that lies between the outer trophoblast layers and the inner fetal blood vessels. It consists of mesenchymal cells embedded in an extracellular matrix containing collagen, fibronectin, and other structural proteins.
What cells make up the chorionic villous mesenchyme?
The chorionic villous mesenchyme contains several cell types including fibroblasts, myofibroblasts, macrophages (Hofbauer cells), and placental mesenchymal stem cells. Hofbauer cells are particularly important as placental macrophages that regulate villous development, fluid balance, and immune defense within the villous stroma.
What are Hofbauer cells and what is their role in villous mesenchyme?
Hofbauer cells are fetal macrophages residing in the chorionic villous mesenchyme. They are derived from fetal hematopoietic precursors and are present throughout pregnancy. Hofbauer cells phagocytose pathogens and debris, regulate trophoblast function, promote villous branching and angiogenesis, and help maintain the immunological privilege of the fetoplacental unit against maternal immune attack.
How does chorionic villous mesenchyme change across pregnancy?
Early in pregnancy, the villous mesenchyme is loose and edematous, reflecting the immature mesenchymal villus. As pregnancy progresses, the mesenchyme becomes more organized and compact in stem villi but remains loose in mature intermediate villi. In terminal villi, the stroma is minimal and contains the highly capillarized fetal vessels. This progressive change reflects the increasing specialization of different villous subtypes.
What pathological changes can occur in chorionic villous mesenchyme?
Several pathological conditions affect villous mesenchyme. Villous edema (hydrops) involves accumulation of fluid within the mesenchyme and can result from immune and non-immune causes. Villous fibrosis occurs in avascular villi following thrombosis of fetal vessels. Placental mesenchymal dysplasia involves abnormal mesenchymal proliferation resembling partial hydatidiform mole but with a normal karyotype.

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Data sources: Terminologia Anatomica, Foundational Model of Anatomy, Wikidata.