Pineal gland
Glandula pinealis
A small, pine cone-shaped gland located posterior to the third ventricle at the epithalamus, between the two superior colliculi. It receives sympathetic innervation via the superior cervical ganglion. Pinealocytes produce melatonin from serotonin in response to darkness signals from the retina.
Function
Produces melatonin, which regulates circadian rhythms (sleep-wake cycles) and seasonal biological rhythms. Melatonin production increases in darkness and decreases with light exposure.
Clinical Significance
Pineal tumors can cause obstructive hydrocephalus due to compression of the cerebral aqueduct. Pineal calcification is a normal finding on CT scans and can serve as a midline marker. Disrupted melatonin production affects sleep disorders and jet lag.
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Related Structures
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